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These results support that KRAS amplification and KRAS mRNA expression, both increasing from primary to metastatic lesions, are relevant for endometrial carcinoma disease progression.
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Amplifications of 8q24, expression of genes downstream from MYC, and overexpression of ATAD2 predicted poor outcome and increased from primary to metastatic lesions.
Meanwhile, microhardness and elastic modulus of primary phase increased from primary γ phase to primary Laves phase, while hardness and elastic modulus of eutectic phases firstly decreased and then increased with increasing Ta content.
Note that, although the values primarily increase from primary screenings to confirmatory assays to summary assays in general, this increase should also not be interpreted to be statistically meaningful, considering that the values increases even more rapidly, as shown in Tables 3-4.
When education increases from primary school to middle school and college, MHKQ score increases by 1.38 and 2.69 points, respectively.
However, there was no significant improvement in knowledge observed when the educational level increased from primary to secondary level.
These co-payments increase from primary to secondary and tertiary care and are highest in case of private facilities.
The amount that patients are required to pay as an out-of-pocket expense increases from primary care institutions to tertiary care institutions.
Furthermore, among boys, total PA decreased less when the implementation score of active schoolyards and playgrounds increased from primary to secondary school while among girls the decrease in total PA was larger when the implementation score of active schoolyards and playgrounds increased from primary to secondary school.
Oncomine copy number data confirmed DIAPH3 genomic loss and its significant correlation with disease progression, which increased from primary tumour to metastatic lesions and with increasing Gleason score [ Fig 1G and H; (Taylor et al, 2010)].
Although not observed in corresponding patients, the finding that the frequency of RB1 alterations did not increase from primary to metastatic lesions argues against a major role for RB1 alterations as drivers during metastatic development.
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