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Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD).
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Although the role of LOXL2 in the maturation of extracellular matrix (ECM) is well established, there is increasing evidence involving LOXL2 in other physiological and pathological processes.
Although most of the cases of HTs described so far concern genes, there is increasing evidence that some involve transposable elements (TEs) in Eukaryotes.
However, there is increasing evidence that oxidant signaling involving NADPH oxidase has other important roles in cell biology.
Additionally, there is increasing evidence that WISP1 is involved in carcinogenesis 48.
As summarized above, there is increasing evidence that BMPs are involved in these processes.
17 There is increasing evidence that HSPGs are involved in inflammation.
There is increasing evidence that inflammation is involved in the pathophysiology of heart failure and diabetes [ 6- 9].
There is increasing evidence that miRNAs are involved in the differential expression of SLE-associated genes [ 11, 12].
There is increasing evidence that hemichannels are involved in cell volume regulation and in programmed cell death (26).
Moreover, there is increasing evidence that MUC1 is involved in tumour growth and antagonism of MUC1 signalling can inhibit this growth 38.
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