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This temporal trend may suggest that increasing environmental exposure is now able to trigger type 1 diabetes in subjects who are less genetically susceptible.
They may rather be attributable to advances in laboratory culture and molecular speciation methods, increasing awareness, increasing environmental exposure, decreasing immunity to mycobacteria and/or aging and increasingly prevalent susceptible populations [ 4, 10, 12, 24].
Swan et al. (2005) demonstrated that anogenital distance, a frequently used end point in rodent developmental toxicology studies, decreased significantly with increasing environmental exposure to phthalates, as reported in prenatally exposed rodents.
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As with other nanomaterials, increased production and use generally leads to increased environmental exposure.
Stacking of Bt genes results in increased environmental exposure to Bt toxins and, thus, in increased risks of effects on non-target organisms.
These findings suggested that even slightly increased environmental exposure to methylmercury from fish could lead to adverse effects on nervous system development, just like inorganic lead exposure.
Children living in an area with increased environmental exposure to Mn may have symptoms of chronic toxicity that are different from adults who experience occupational exposure.
Of the children included in our study, 73.9% of the patients were from rural areas, suggesting that there is increased environmental exposure in rural areas.
Low socioeconomic status has been associated with increased environmental exposure to tobacco smoke, 43 inadequate nutrition, 22 little understanding of the underlying disease, 44 45 and poor treatment adherence.
It is not clear whether the difference between cases and controls is due to increased environmental exposure or genetic differences in lead metabolism.
The hypothesis of our study was that children living in an area with increased environmental exposure to Mn will have symptoms of chronic Mn toxicity.
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