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Exciting developments in cancer nanomedicine include the engineering of nanocarriers to deliver drugs locally to tumors, increasing efficacy and reducing off-target toxicity associated with chemotherapies.
Targeted radiotherapy using radiolabelled meta-iodobenzylguanidine (MIBG) is a promising treatment option for bladder cancer, restricting the effects of radiotherapy to malignant cells thereby increasing efficacy and decreasing morbidity of radiotherapy.
The technology allows us to optimize on that existing clinical foundation by getting the drug into the right place at the right time for the right duration, thereby significantly increasing efficacy and reducing toxicity, but without the technology risk that plagues so many drugs, particularly in oncology, where the animal models don't translate because human and animal biology are so different.
HA is a promising candidate for increasing efficacy and reducing toxicity of cancer therapies.
Thus, once-daily dosing may increase the therapeutic-toxicity ratio by increasing efficacy and decreasing adverse effects [ 57].
2, 3 These changes show the positive effects of increasing efficacy and effectiveness, but they also raise the question of what happens to the consumption of resources.
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Antibody-drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy.
Here, the authors review how the current therapeutic antibodies work and how they might be enhanced to increase efficacy and extend their use.
Whether novel melphalan formulations such as FDA-approved propylene glycol-free melphalan have increased efficacy and decreased toxicity compared to melphalan is to be investigated.
During the last few decades, an increasing number of drugs targeting DNA methylation have been developed to increase efficacy and stability and to decrease toxicity.
New approaches to allergen immunotherapy, designed to increase efficacy and safety, include conjugation of allergens to immunostimulatory sequences and encapsulation in liposomes.
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