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Some sites already use a version of this approach; Wikipedia users can earn increasing editing rights by gaining the trust of other editors, and when reviews are posted on Amazon.com, those displayed most prominently are those that readers have voted "most helpful" — and they are often written under real names.
Similarly, the 'DCS zip' mutation shows decreased thermo-responsive editing patterns at all three sites compared to the loxP control, in addition to increasing editing in all conditions, as expected [ 8].
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We also found that cells with intact mismatch repair system had reduced chance to escape CRISPR mediated cleavage and yielded increased editing efficiency.
The low editing observed is in agreement with previous studies that showed increased editing levels within protein-coding regions during development [31], [32], [33].
Our data suggest that increased editing at the AMPA R/G site, by altering resensitization kinetics, could enhance the receptor response to glutamate, resulting in a synapse operating at an increased gain.
Thus, PWS is often marked by increased editing of 5-HT2CR.
Thus, an investigator can choose between the additional cost for the increased editing efficiency or simply inject more P0 animals and screen more F1's.
Nevertheless, there appears to be a trend of increased editing of 5-HT2CR, whish is associated with decreased sensitivity of the receptor, in the case of suicide victims.
This results in increased editing at all three sites in paralytic, but also results in a splicing defect and a temperature-sensitive phenotype [ 8].
The 'DCS delete' mutation, which is predicted to decrease secondary structure, decreases editing at all three paralytic editing sites, while the 'DCS zip' mutation, which increases secondary structure, is known to increase editing at all three sites [ 8].
Another study looked at suicide victims who had a history of major depression and found increased editing of the C and E sites, whereas the D site was found to show decreased editing [ 49].
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CEO of Professional Science Editing for Scientists @ prosciediting.com