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Increasing dosing frequency can aggravate patient compliance issues, unless an increase in dosing frequency can lead to a significant reduction in treatment duration.
A mathematical model predicted a larger effect on half-life with increasing dosing frequency than observed in the current study [ 8].
That is, therapeutic levels should be achieved in these cases by administering smaller maintenance doses or by increasing dosing intervals to avoid accumulation of this agent in the body.
Due to incomplete control of disease activity, five patients (one with MWS/CINCA and four with CINCA) experienced increasing dosing during the trial and were therefore receiving 4 mg/kg (or 300 mg, if body weight was > 40 Kg) every 8 weeks (Table 1).
Findings from an observational study have suggested that treatment adherence among patients with COPD declines with increasing dosing frequency (29), but this appears to be a greater concern for three- and four-times-daily regimens, and there is a lack of evidence to support greater adherence to QD versus BID treatment in practice.
Similar(55)
Increasing doses of NESP corresponded with increased efficacy.
Only "increased appetite" showed a significant dose association, the incidence of which increased with increasing dose.
With increasing doses of caffeine, we sustained higher gradients and felt stronger.
But as the depression deepened, I capitulated, using antidepressants in various combinations and at increasing doses.
In 2004, he started taking small, and then increasing doses of the drug.
Patients are given increasing doses of the drugs while scientists monitor side effects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com