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The algorithm is progressive: similar sequences are aligned first, with increasing distant ones added to this foundation.
These provocative findings [ 5] (and similar work by Pàez-Ribes and colleagues [ 9]) suggest that in trying to do good with adjuvant anti-VEGF therapy we might create the great harm of increasing distant metastatic disease.
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This IL-6 trans-signaling also increased distant metastasis in vivo.
This shows that β2AR signaling increases dissemination from explanted tumors, suggesting a possible mechanism for increased distant metastasis.
In their study of postmastectomy chest wall relapse, COX-2 protein expression correlated with increased distant metastasis [ 27].
One report of young adults enrolled in cooperative group studies shows an inferior outcome for young adults due to increased distant relapse.
in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71 9.58; p = 0.006).
We speculate that the increased distant recurrence rate after radiation in high-AEG-1-expressing tumours could be because of the metastasis-promoting properties of AEG-1.
Our PCa mouse model clearly demonstrated that increased CCL2 and EMT markers in AR silenced PCa cells were associated with increased distant metastasis, in spite of reduced size of orthotopic AR silenced primary tumours.
However, endothelial barrier function alterations and increased vascular permeability might contribute to hastening tumor cell extravasation, causing progression to stages of greater malignancy, with heightened invasiveness and, in some cases, increased distant metastasis.
In a recently published study, mice with mammary cancer subjected to chronic stress had neuroendocrine activation that did not affect growth of the primary tumors but increased distant metastases 30-fold.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com