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The order of increasing dissolution rate was found to be ATR < PM < SD (kneading method) < SD (solvent evaporation method).
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Cilostazol engineered habits showed increased dissolution rate than unprocessed drug but similar dissolution rate when compared to micronized cilostazol.
In vitro release showed increased dissolution rate of the drug for Sim-NS followed by Sim-SAS and plain drug.
These results indicated that NS-GNDP possessed superiority with improved storage stability and increased dissolution rate and oral bioavailability.
Dissolution measurements demonstrated that a significantly increased dissolution rate was obtained with the amorphous solid dispersion compared to the physical mixture.
In the meantime, the hydrolysis (cathodic reaction) occurs inside the pit giving rise to a lower pH and leading to an increased dissolution rate of the metals.
In the transpassive region, strong thickening of the oxide film takes place, combined with a change in the composition of the film, and strongly increased dissolution rate.
Leroux et al. [12] have demonstrated significant improvement in bioavailability for HIV-1 protease inhibitors using pH sensitive nanoparticles, as the smaller particle size can increase surface area resulting in an increased dissolution rate and bioavailability.
The fact that limited direct uptake of nanoparticle in Caco-2 cells suggested that the improvement of oral bioavailability [27] by the particle size reduction is via increased dissolution rate rather than direct uptake.
The observed limited direct uptake of nanoparticles in Caco-2 cells suggests that the improvement in oral bioavailability by particle size reduction is via increased dissolution rate rather than direct uptake.
Reducing particle size of salt to approximately 1.5 µm would increase its surface area, leading to increased dissolution rate in saliva and more efficient transfer of ions to taste buds, and hence, perhaps, a saltier perception of foods.
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