This is the case, however, regardless of whether the cost of resistance decreases or increases clearance rate.
Interestingly, 2-hydroxyestrogen but not 16α-hydroxyestrogen has increased clearance rate from the circulation of premenopausal females smokers [ 44, 45], suggesting a differential effect of estrogen metabolism.
Similarly, MC increased clearance rates of HR-HPV infections at the coronal sulcus in the Uganda RCT [ 2].
In patients with congenital FVII deficiency, increased clearance rates of rFVIIa may be linked to the absence of endogenous production of functional FVII/FVIIa.
Three other patient groups also had increased clearance rates relative to normal levels, namely, patients with congenital FVII deficiency, paediatric patients with haemophilia, and patients with UGIB and cirrhosis.
This effect could have arisen if the host acts as a virus filter, so only some HCV viruses can infect hosts that have IL28B genotypes that increase clearance rate.
Thus, increasing the clearance rate for the anti-VEGF and VEGF/anti-VEGF complex impedes the therapeutic action of the anti-VEGF agent in the tumor.
The numerical results suggest that the most effective methods of reducing both the basic reproductive number and the chronic infection CD4+ T-cell and virus populations are the following: (1) to increase the efficacy of the antiretroviral treatments and (2) to increase virus clearance rate, decrease infection rate, or decrease viral reproduction rate.
From the numerical results in Table 12, it can be seen that the most effective methods of reducing (R_{0}) are the following: (1) to try to increase the efficacies (n_{rt}) and (n_{p}) of the antiretroviral therapy and (2) to increase virus clearance rate c, decrease infection rate k, or decrease viral reproduction rate N. Chronic case ( (R_{0} approx 1) ).
From the numerical results, it can be seen that the most effective methods of reducing (R_{0}) are the following: (1) to try to increase the efficacies (n_{rt}) and (n_{p}) of the antiretroviral therapy and then (2) to increase virus clearance rate c, decrease infection rate k, or decrease viral reproduction rate N.
