Sentence examples for increasing circulation time from inspiring English sources

The temperature of the upper part of the wellbore increases with the increasing circulation time and drilling displacement, and the lower part of the wellbore decreases with the increasing circulation time and drilling displacement.

The use of polymeric coatings can also lead to other key benefits, such as increasing circulation time, improving bioavailability of encapsulated drug, increasing targeting efficiency, and altering surface charge of the liposomes [49].

Previous studies in literature show the uptake of SLNs from the intestinal lymphatic system thus bypassing first pass metabolism in the liver, increasing circulation time, reducing dosage and ensuring high bioavailability of the drugs [ 40– 40].

Background: Liposomal cisplatin is a new formulation developed to reduce the systemic toxicity of cisplatin while simultaneously improving the targeting of the drug to the primary tumor and to metastases by increasing circulation time in the body fluids and tissues.

One area to investigate is whether or not the strength of binding to plasma protein, while increasing circulation time, may show an inverse relationship to toxicity, given the lack of residence time in target organs.

We hypothesize that the HA coating, besides targeting the tumor, also prevents the interaction of the CAHA-sSWCNT formula with plasma proteins, thus increasing circulation time, and consequently the leaky vasculature of the tumor allows for increased uptake of the nanoparticles, which explains the increased therapeutic efficacy of the drug-loaded nanoparticles.

To utilise PEG for increased circulation time, the ratio of PEG to targeting ligand has to be optimised.

The main goals of these vehicles are to provide improved drug disposition Putney (1998), protection from metabolic degradation Dziubla et al. (2005), and increased circulation time Putney (1998).

The most broadly used polymer is polyethylene glycol (PEG), which reduces their uptake by the reticuloendothelial system (RES) and increases circulation time when compared with uncoated counterparts [9 11].

Phosphorothioate ONs bind serum proteins, leading to reduced renal clearance and an increased circulation time.

The increased efficacy with transferrin liposomes could be due to increased circulation time and transferrin mediated endocytosis of liposomes into cancer cells.