It was postulated that the potentiation of the efficacy of cisplatin by β-elemene was due to inducing cell cycle arrest in NSCLC cells at the G2/M phase by increasing checkpoint kinase 2 (CHK2) expression and reducing Cdc2 activity [ 71].
Add to that the fact the government has stepped up its anti-trafficking efforts since the quake – using media campaigns and increased checkpoints on main roads and at the airport to tackle the problem – and it's hard to know whether the number of people being trafficked has risen over the past six months, or whether the authorities are just getting better at finding them.
In ddc1 T602A or ddc1 T602A dot1Δ mutant strains, addition of the dpb11Δ C mutation did not result in increased checkpoint defects as measured by Rad53 phosphorylation and survival after phleomycin treatment.
The Met said that since 2011 it had increased roadside checkpoints, automatic number plate recognition (ANPR), fixed cameras and routine number plate checks.
Now, many people are afraid to venture out at night, fearing the army, which increases its checkpoints after dark, as much as the militants.
The police will draw a tight perimeter around the city, with increased truck checkpoints and stepped-up Harbor Unit patrols on waterways.
In response to the attacks, the Rafah border post into Gaza was closed and security increased at checkpoints on the peninsula.
For example, in 2005 81% of KAP survey respondents were in favor of sobriety checkpoints, increasing to 93% in the 2008 KAP survey (Table 3).
BRCA1 interacts directly or indirectly with numerous molecules [ 53], which is consistent with the observation that BRCA1 deficiency results in pleiotropic phenotypes, including defective DNA damage repair, defective cell cycle checkpoints, increased apoptosis, impaired spindle checkpoint and chromosome damage [ 54, 55].
Fortunately, he said, he has Burmese staff members who are permitted to pass through an increasing number of military checkpoints.
