However, its Arabidopsis homolog (AGG3) promotes seed and organ growth by increasing cell proliferation (Li et al., 2012).
Although upregulation of PLD1 plays an important role in increasing cell proliferation, the molecular mechanisms mediating PLD1 expression in GC cells are still unclear.
Cellular response was different for the different morphologies, with spherical particles exhibiting no cytotoxicity to HFF cells, rod-like particles increasing cell proliferation, and platelet particles markedly cytotoxic.
The MAPK pathway has recently reported to control grain size by increasing cell proliferation in spikelet hulls (Duan et al., 2014; Liu et al., 2015).
Under dynamic conditions, medium flow through the channels improves nutrient availability to the cells on the various layers, drastically increasing cell proliferation on all layers.
Silencing EphB2 stimulated pancreatic carcinoma growth by increasing cell proliferation through G1/S phase breakthrough, which relied on a CyclinD1/CDK6 cell-cycle regulated signal.
Our findings indicate that CrHFC with AuNPs accelerate wound healing by increasing cell proliferation and subsequent regulation of collagen synthesis/degradation as well as alteration of type I and III collagen composition in the injury site.
These results indicate that PTHrP may play a role in colon cancer invasion and metastasis by increasing cell proliferation and adhesion to the ECM via upregulation of proinvasive integrin expression.
In particular, PI3 K Akt mTOR signaling, plays an important role in coordinating metabolism and promoting cell survival, and the specific contributions of Akt hyperactivation to oncogenes have been attributed to its fundamental roles in cellular energy metabolism of inhibiting apoptosis, increasing cell proliferation, and accelerating oncogenic mutation rates [18].
In contrast, SL scaffolds displaying a bigger pore size, higher porosity and crystallinity resulted in homogenous cell distribution, increasing cell proliferation and advanced chondrocyte differentiation in terms of their spherical morphology, predominant chondrogenic gene expression and abundant cartilaginous extracellular matrix production.
Low concentrations were pro-angiogenic with 0.1 µM simvastatin significantly increasing cell proliferation, and 0.01 µM simvastatin significantly promoting cell migration, sprouting, and tubulogenesis.
