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Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death.
The images also indicated that the nanoparticles induced increasing cell death in a concentration-dependent manner but with no disturbance of cell membrane integrity (Figures 3A and 4A).
These results suggest that in a prolonged oral treatment regime, vitamin D3 may provide for improved CaP sensitivity to cryoablation thereby increasing cell death while reducing the need for an enlarged positive freeze margin.
The present results show that IFNγ influences NPCs in two ways by decreasing cell proliferation and by increasing cell death.
The cell proliferation, division, as well as nucleotide synthesis pathways were found diminished, confirming increasing cell death and DNA damage at this late stage of disease pathogenesis.
Reduced angiogenesis in Cstc+/+ mice may affect nutrient supply, thus increasing cell death and reducing proliferation, although a detailed mechanism of cathepsin function in this SCC cancer model requires further investigation.
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Loss of pRb results in an increased signaling of DNA damage pathways and to increased cell death [47].
The MBMAE increased cell death also in hippocampal cell cultures.
ZnO induces oxidative stress, decreases viability, and increases cell death in Caco-2 cells.
We observed that overexpression of wild type MCU significantly increased cell death induced by H2O2.
CrVI disrupts placental histoarchitecture and increases cell death by spatiotemporal modulation of apoptotic signaling.
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