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Numerous case reports of malignant seeding resulting from needle biopsies have been reported for different tumours (Boutin et al, 1995; Herts and Baker, 1995; Jones et al, 2005; Vaghefi et al, 2005; Al-Leswas et al, 2008) and increasing caution is observed in highly aggressive malignancies, for example in the pancreas (Micames et al, 2003).
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The first explanation (i.e., increased response caution) is that an error prompts people to accumulate more information before they initiate a decision.
"There is no question that the economy continues to be difficult and consumers are reacting with increasing caution," said Chairman Tom Ryan Tom Ryan, adding that December same-store sales will be well below growth of 4.3% in October and 6.1% in November.
The embattled oil company is due to start exploring 60 miles off the Shetland Isles in October, at a time when governments around the world are showing increasing caution about deep-sea drilling following the Gulf of Mexico disaster, the worst oil spill in history.
Adam Challis, head of residential research at the real estate services firm Jones Lang LaSalle, said HTB should be used with increasing caution and not as a political tool.
Regression analysis between mass nitrogen reduction and theoretical retention time (7.5 79 h) suggested minimum design retention times should be increased, though caution was also issued about this as increased design retention times and corresponding larger bioreactors may exacerbate detrimental by-products under low flow conditions.
Still, some signs indicate that investors are looking at the high-flying sector with increasing caution.
In terms of relative risk, this could mean either a 20% reduced or about 100% increased risk, therefore caution is justified when recommending routine screening in this population.
Early this year, the deflation talk helped to increase caution, and there was worry about what would happen as a result of war in Iraq.
This may suggest that while the number of annually registered trials increased, the proportion of trials registered may not have increased as much (however, caution is warranted in drawing such conclusions; we used countries' expenditures on health research as a proxy for the number of trials being conducted in a country, but these two are not necessarily linearly correlated).
Dr John Swenson-Wright, head of the Asia programme at the Chatham House think-tank, said that while there was "growing evidence of the North's increasing technical sophistication", caution was necessary in interpreting North Korea's latest statement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com