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Urine DPD level was increased in all OVX groups independent of ITAM status, indicating increasing bone resorption.
Proinflammatory cytokines, such as TNF, are believed to play a central role in this process by increasing bone resorption.
In addition to increasing bone resorption, osteoclast products can activate and sensitise peripheral nerves and increase pain signalling.
We showed clear associations between increasing cadmium body burden, on one hand, and decreasing BMD, increasing bone resorption (U-DPD), and decreasing PTH, on the other.
Akesson et al. (2006) reported associations between increasing overall Cd levels and decreasing forearm BMD and a direct effect on bone, that is, increasing bone resorption.
The classical active form of vitamin D plays a major role in increasing the serum calcium concentration by promoting absorption of calcium from the intestinal tract or increasing bone resorption [ 10].
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Both decreased bone formation and increased bone resorption (in different amounts) are observed.
Dysregulated inflammation leads to increased bone resorption and suppressed bone formation.
Increased bone resorption, and probably decreased bone formation are involved in the process of bone lesion caused by iron overload.
Low cytokine levels suggest that these factors do not mediate the increased bone resorption of AN. (J Pediatr 2002 141 64-70).
These data are the first to suggest a relationship between DHEAS and increased bone resorption in AN.
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