Sentence examples for increasing affinity to from inspiring English sources
It is seen from Eq. 2 that the value of ftb (1) increases with increasing target density, (2) decreases with increasing non-specific binding (Vu,brain), and (3) increases with increasing affinity to the target protein (Kd).
Previous studies assessing the safety of anti-VEGF antibodies, including bevacizumab, demonstrated increased hepatic and renal damage with antibodies of increasing affinity to VEGF.
The poly(A) tail binds to numerous polyadenosyl-binding proteins (PABP), which recruit eukaryotic initiation factor 4G (eIF4G), leading to circular mRNA by increasing affinity to the mRNA cap [24].
When we checked the receptor binding activities of one series of bisphenol derivatives (i.e., bisphenol E, BPA, bisphenol B, bisphenol AP, and bisphenol AF), we found this line-up to be the order of compounds with increasing affinity to ER-α.
We then investigated whether an increase in the number of RBFOX1/2 motifs was associated with increased affinity to RBFOX1/2 RRM.
However, the chimeric dscuPA33khC bound the activated platelet and significantly increased affinity to platelet clots as compared to fibrin clots.
We designed and synthesized a Sulindac analog K-80003, which has increased affinity to RXRα but lacks COX inhibitory activity.
Binding assays indicated that the Ii-Key/HPV16 hybrid has increased affinity to HLA-DR4+ cells relative to the epitope-only peptide, which may explain its increased potency.
Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand protein interactions and design analogues with increased affinity to Pgp.
The results showed not only that the rhBMP2 CBD had an increased affinity to collagen, but also that this binding was very stable during a prolonged period of time.
In the present study, we report that a sustained depolarization slowly inactivated (half-time = 10 15 min) ROMK channels that had been engineered for increased affinity to internal polyamines.
