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These side effects will be more frequent with increasing administration of anti-CTLA-4 treatment.
Antibiotic resistance appears to have contributed to increasing administration of inadequate antimicrobial therapy for nosocomial blood-stream infections, which is associated with greater hospital mortality rates [ 40, 41].
The global spread of antimicrobial resistance has become a pressing problem, with a focus on the ICU due to the increasing administration of ineffective antimicrobial regimens associated with greater morbidity and mortality [ 9, 10].
It is possible that other types of critically ill patients (neonates, cardiothoracic patients) may have different rates of pre-admission antimicrobial treatment and different risk factors predisposing to increasing administration of antibiotics.
Worryingly, issues of vaccination programme affordability and sustainability were largely ignored, though one study [ 17], noting the increasing administration of vaccines by the private sector, explored the impact of using private sector prices in delivering the intervention.
Given the association of antibiotic resistance with increasing administration of IIAT and greater hospital mortality, several strategies have been developed to improve upon the appropriateness of empiric therapy in patients at risk of infection with P. aeruginosa and other antibiotic-resistant pathogens.
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This could also be related to an increased administration of HFNCT to patients usually treated with standard oxygen treatment.
An increased administration of fluids has been reported to enhance microcirculation at the early phase of sepsis [ 45].
Initially, serum chloride levels slowly increased, administration of i.v. pantozole led to a rapid increase into the high normal range (figure 3).
It was presumed that the level of anaesthesia was insufficient and was followed by the increased administration of propofol (10 mg/kg/h).
Organisation of formal care processes with rapid care pathways has been shown to be associated with faster times to treatment and increased administration of alteplase [ 8- 10].
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