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These data demonstrate that eIF4E specifically increases the translation of a subset of mRNAs.
Phosphorylated eIF2α selectively increases the translation of Atf4, a basic-leucine zipper (bZIP) transcription factor that up-regulates ER-resident chaperones [1], [2].
Although phosphorylation of eIF2 α causes a global inhibition of protein synthesis, it increases the translation of rare mRNAs containing upstream open reading frames, such as ATF4.
HER2 overexpression increases the translation of fatty acid synthase (FASN), and FASN overexpression markedly increases HER2 signaling, which results in enhanced cell growth.
However, it specifically increases the translation of factor activating transcription factor 4 (Athat that protects cells from damaging effects of ER stress (Blais et al, 2004).
Furthermore, activation of the phosphoinositide 3-kinase (PI3K /PKB pathway increases the translation of c-Myc [ 50] and cyclin D1, and stabilizes D-type cyclins [ 75- 77].
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Patients without a confirmed source of infection (as this could increase the translation of the study to other critically ill).
We then combined the most effective 3′ CITE and a 5′ enhancer to further increase the translation efficiency.
We will analyze the effects of resuscitation strategies on the primary outcome in the following subgroups: (a) Patients with lactate > 4.0 mmol/L as set by SSC [10] (b) Patients without a confirmed source of infection (as this could increase the translation of the study to other critically ill).
Hsp90 cis-regulatory element regulates hsp90 in Drosophila, increasing the translation rate of the heat shock protein at high temperatures.
SmpB is thought to be limited to trans-translation but has been shown to increase the translation of a single protein - the stationary phase sigma factor RpoS [19].
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