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Performing a manual review of the slide when the instrument yields identical results reduces the efficiency and productivity of a laboratory and increases the imprecision of the results [ 11, 12].
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Furthermore in that case, the velocity was not scaled considering the factor cos in Eq. (2), which would in addition increase the imprecision.
However, taking into account the lower sensitivity of chromogenic assays compared to LC-MS/MS and the variability of coagulation analysers that may further increase the imprecision at the lowest concentrations, detection and quantitation of lower levels (<30 ng/mL for rivaroxaban and <15 ng/mL for apixaban) still require LC-MS/MS analyses [ 108, 109].
Nevertheless, taking into account the lower sensitivity of chromogenic assays compared to LC-MS/MS and the variability of coagulation analysers that may further increase the imprecision at the lowest concentrations, detection and quantitation of lower levels (<30 ng/mL) in rivaroxaban treated patients still require LC-MS/MS analyses [ 50, 77].
The addition of steps into the sample preparation procedure usually increases the overall imprecision of the method.
The achieved LODs were generally much lower than for previously described methods (Huang et al. 2009; Silva et al. 2004; Wittassek et al. 2009), although the imprecision might increase at the lowest levels.
While the first approach has a relatively wide reference range and is very dependent on experimental conditions (e.g. concentration of added Tg, and two measurements of Tg that increase overall imprecision), the second approach will, depending on the assay, detect most TgAb-positive patients.
When the imprecision of the fish variable increased, the adverse mercury effects became stronger and more significant.
Similarly, the other outcomes showed stronger mercury effects when the imprecision in the fish variable was increased.
Given the imprecision of our estimate of 2.3% increased mortality per degree of cold (CI 0.7%to3.8.8%), we do not translate it to a quantitative burden.
Although prefetching reduces the response time of a requested document, it also increases the network load, as some documents will be unnecessarily prefetched (due to the imprecision in the prediction algorithm).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com