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In our study, we found that hypoxia significantly increases the expressions of DNMT1 and DNMT3a, but does not affect the methylation of NEP promoters (Figure 6A).
FFA induces the over-expression of TGFBRII as noted in diabetic kidney disease [100] and it increases the expressions of proto-oncogenes and SMAD3 in TGFB signalling process [101].
GSH also increases the expressions of costimulatory molecules such as HLA-DR, CD80 and CD86 on the cell surface of DCs.
Previous studies have indicated that NE increases the expressions of elafin, MUC4 and MUC5AC, and the secretion of elafin and mucin in LE cells.
LOX-1 activation with oxLDL increases the expressions CD40 and CD40 ligand and subsequent generation of tumor necrosis factor-α (TNF-α) and P-selectin via protein kinase C (PKC) activation in human coronary artery endothelial cells [ 15].
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These tests have found that it increases the expression of dormant HIV genes fivefold.
Complement increases the expression of CD18 on the neutrophils and increases P-selectin expression on the surface of the endothelium.
Consequently, hyper-acetylated ChREBP increases the expression of lipogenesis-related genes in the liver.
MRG2 directly binds to FT and increases the expression of FT in an H3K36me3-dependent manner.
HIF-1α increases the expression of miR-155, which in turn represses HIF-1α expression following sustained hypoxia [21].
The study authors have also shown that the minor allele of rs1835740 increases the expression levels of MTDH [57].
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