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Previous studies have shown that BPA treatment increases StAR and P450scc mRNA expression in cultured T-I cells (Zhou et al. 2008) but decreases StAR, P450scc, and 3β-HSD in antral follicle cultures (Peretz et al. 2011).
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Then we investigated how long the increased StAR expression and the single CpG demethylation could last.
To extend the functions or improving the performances of the devices, CPs frequently have to be blended with other functional materials to form composites. Graphene, a one-atom layer of graphite with unique two-dimensional structure and excellent mechanical and electrical properties, has become an increasing star in material science.
On the other hand, specific inhibition of PTGS2 was also associated with increased StAR expression [ 17].
In isolated rat granulosa cells, BPA (100 μM) decreased progesterone synthesis and increased StAR expression (Zhou et al. 2008).
The present data are also consistent with previous studies that demonstrated stimulation of MA-10 cells with a cAMP analog coordinately increased StAR mRNA, StAR protein and steroid production (10, 20, 37).
It has been demonstrated that LH, its "superagonist" hCG, and analogs of their second messenger, cAMP, (dibutyryl cAMP, 8-bromo-cAMP), coordinately increase StAR protein and StAR mRNA levels in a time frame that is consistent with increased steroid production in mouse Leydig cells (10, 19- 21).
Interstitial spaces were increased (stars) with compensatory hyperplasia of Lyedig cells (white star) (H-E, × 200).
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CEO of Professional Science Editing for Scientists @ prosciediting.com