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Data suggest that obesity increases serum urate by eliciting both increased production and decreased renal excretion of urate [ 36].
The conversion of the increased amounts of testosterone to estrogen in peripheral tissues increases serum estrogen concentrations in males.
In response to low ionized calcium, the parathyroids increase secretion of parathyroid hormone (PTH) which increases serum calcium.
Supporting this hypothesis, we found that a single injection of FBP markedly increases serum concentration of adenosine, which was completely abrogated by inhibition of CD39 or CD73.
MicroRNA (miR -33 targets ATP-binding cassette transporter A1 (ABCA1), and its deficiency increases serumiR -33holestargetsHDL-C) and ameliorates atheroscassette.
Maternal treatment with dexamethasone during lactation alters reproductive functions and increases serum corticosterone in the male offspring.
This results in an increase in PTH in the circulation, which increases serum calcium and decreases serum phoshorus because of the enhanced excretion of phosphorus into the urine.
It also increases serum insulin and body weight.
Thus, given a nanodelivery system, better distribution increases serum half-life and wider application both in parenteral and nonparenteral administration.
For instance, it was reported that LPS increases serum PAF-AH activity in Syrian hamsters [29].
Reduced activity of hepatic SR-B1 impedes HDL clearance and increases serum HDL levels [45], [46], [47].
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