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Addition of these EST- and BAC-based SNPs to the bovine linkage map not only increases marker density, but provides connections to gene-rich physical maps, including annotated human sequence.
From these data, we extrapolated the sample size for which the addition of 10 individuals increases marker density by <1 %; this marker saturation is achieved with 90 and 110 individuals for the CEU and YRI populations respectively.
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Teriparatide (parathyroid hormone [PTH] 1-34) adminitiallyon increases increases markers of bone formation, followed by an increase in bone resorption markers.
Increasing marker duration did not produce an overestimation of the empty time intervals.
Our results demonstrated that Cd administration induced an increased marker enzyme activity in plasma.
Additional markers are being added to allow interval analysis for putative quantitative trait loci that have been identified and to increase marker density.
Therefore, we suggest the QTLs identified in the present study may be further reconfirmed by increasing marker density and size of the association panel.
In general, increasing marker density can increase the resolution of the genetic map, thus enhancing the precision of QTL mapping.
Increasing marker density ten times to 4,800,000 may not increase power significantly since the mean r2 only increases to 0.207 (median r2 = 0.096).
Second, having identified increases in the variance of each of these measures with increasing marker number, we apply a normalising transformation to make our heterozygosity data statistically comparable.
The observed fluctuations of sample points around the representative points may also reflect effects from subtle population structure and cannot be reduced by increasing marker numbers.
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