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Polyethylene glycol (PEG) modification of a chimeric Fab' fragment (F9) of A5B7 (alpha-CEA), using an improved coupling method, increases its specificity for subcutaneous LS174T tumours.
Additionally, it has been demonstrated that the inclusion of fever in the WHO criteria for the clinical diagnosis of CAP substantially increases its specificity, particularly in children with wheezing [ 21].
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Descended from lobe-finned fish, the SCTR-like sequence gradually increased its specificity and sensitivity towards the newly appeared SCT, until it became fully functional as a specific receptor for SCT; and as a result, functions of VIP/PACAP and SCT were independently regulated in tetrapods.
Lee, J. K. et al. Directed evolution of CRISPR Cas9 to increase its specificity.
As Wang continues to refine his method, he aims to increase its specificity and ensure his capture compounds bind to the exact same proteins they would inside a live cell.
Therefore, the assessment of miRNAs in sputum might be useful to augment CT, particularly increase its specificity, for the early detection of lung cancer.
Additional conditions regarding the maximum packet size, the target ports, the state of the connection, and the exact format of the identification string are introduced to increase its specificity.
In general, r values greater than 0.4 decreased the sensitivity of the algorithm by excluding increasing numbers of putative orthologs, but increased its specificity.
Incorporating the conservation of phosphorylation motifs across related species into the model might also increase its specificity by adding additional biological restraints.
These results showed that this structure not only enhanced the efficiency of the DNAzyme, but also increased its specificity by minimizing the side effects, i.e., digestion of non-target mRNA.
However, the overall benefit of this modification is the increased its specificity towards the VL vector.
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