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In contrast, the overexpression of LCN2 in PANC1 cells significantly increases invasion, attachment and tumor growth (Leung et al., 2012).
Of particular relevance, TGFβ1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate cancer cells [39].
Our data demonstrates that both LCN7 overexpression and administration of highly purified recombinant LCN7 proteins increases invasion of two distinct endothelial cell lines.
Moreover, SOX2 increases invasion capacity, which is related to EMT modulation via snail expression.
In fact, it has long been hypothesized that phenotypic plasticity increases invasion success (Baker 1965).
Fusion of MSC with gastric epithelial cells increases invasion and metastasis of gastric cancer [ 32].
Similar(36)
Regarding invasion, increased activity of ezrin contributed to increased invasiveness of Hep3B cell as shown increased invasion of matrigel invasion assay.
Thus, we conclude that an increased number of focal adhesions is correlative with increased invasion.
MSS11 overexpression restores invasive capability and flocculation in S288c and leads to increased invasion and floc formation (~12%) in Σ1278b.
Conversely, Snail overexpression increased invasion and migration of gastric cancer cells, in line with increased VEGF and MMP11.
Neutrophils promote tumour progression by increasing invasion and metastasis through releasing proteases1,2, increasing angiogenesis3,4 and directly promoting tumour growth5,6,7.
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