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Gene duplication increases gene expression diversification and that diversification seems to correlate positively with different measures of the rate of coding region evolution (Li et al. 2005 and references therein).
In the absence of inducer, promoter activity is fully repressed; addition of inducer rapidly increases gene expression by four to five orders of magnitude.
The GAL1 promoter increases gene expression 1000 fold in the presence of galactose in media without glucose, thus providing a major overproduction of the corresponding protein [39].
A wide range of studies have demonstrated that using electroporative DNA administration in small [3], [4] as well as large [5], [6] animals greatly increases gene expression and also induces impressive immune responses.
This is biochemically associated with a significant increase in the phosphorylation of PKA-dependent substrates, which increases gene expression and the activity of the indirect MSN, producing locomotor depression (reviewed in ref. [4]).
Because our hypothesis is that the duplication increases gene expression and thus alters behavior, we also examined the relationship between the duplication and Glo1 expression in the amygdala (Figure 4C; p<0.000001) and the relationship between Glo1 expression in the amygdala and anxiety-like behavior (Figure 4D; p = 0.0012).
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At specific promoters, hydroxymethylation correlated with increased gene expression.
Increasing the histidine residue from 0 to 5 to 10 further increased gene expression efficiency.
Increased gene expression of antimicrobial peptides (BNBD4, DEFB10, and DEFB1) occurred on the day of calving.
A minimal model correctly predicts the increased gene expression variability across mutants.
This could be partly related to the increased gene expression of PPARγ in muscle tissues.
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