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The results suggest that active sensitization per se increases cough reflex sensitivity accompanied by increased inflammatory cells and substance P level in BALF, and antigen challenge further increases them, while simple IgE- and/or IgG-mediated allergic reaction per se or the low intensity of eosinophil infiltration in the airway itself may not affect cough reflex sensitivity in guinea pigs.
We do not know why antigen challenge increases cough reflex sensitivity in atopic cough, but not in asthma.
PGI2 increases cough reflex sensitivity of the asthmatic airway, suggesting that inhibition of PGI2 may be a novel therapeutic option for patients with asthma, especially cough predominant asthma.
A different theory for the pathogenesis of cough in IPF proposes that mechanical distortion of the larger airways by progressive interstitial fibrosis, so-called 'traction bronchiectasis' increases cough sensitivity by altering sensory innervation of the airways [ 39].
Similar(56)
ETS increases susceptibility to respiratory infections [ 141, 142] causes adverse respiratory health outcomes [ 143] and increases coughing illnesses [ 144, 145].
Indoor biomass combustion increases coughing illness associated with acute respiratory infections with an exposure-response effect [ 148].
In other words, airway inflammatory processes such as cell and mediator response following antigen-antibody reaction may be important in increasing cough reflex sensitivity associated with increased levels of substance P.
Children raised with exposure to environmental tobacco smoke experience increased cough and wheeze.
Open image in new window Fig. 1 A 39-year-old male with increasing cough, night sweats and weight loss since 2 months.
On February 24, fever, headache, weakness, anorexia, increasing cough, and shortness of breath developed in the patient.
Bradykinin may act on neural mechanisms that modulate symptoms, increasing cough and dyspnea in asthmatic patients.
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