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Here, we replicated a main finding of these studies showing that DA increases action potential firing evoked by somatic current injection over a wide range of concentrations.
Although glucose also increases action potential frequency (+200%; Figure 2), this is insufficient to compensate for the reduced exocytosis (−75%; Figure 5A).
Thank you for submitting your work entitled "Knockout of SLO2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons" for peer review at eLife.
Activation of nAChRs on interneurons increases action potential firing and augments the frequency of GABAergic inputs to pyramidal neurons (Alkondon et al. 2000; Ji and Dani 2000; Couey et al. 2007).
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Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com