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As for animals in the wild, "[t]hey lose food, the water evaporates and so becomes short in supply and maybe tainted, and they are subjected to increased wild fire risk.
In essence, it is irrelevant if mutated or increased wild type TRPC6 is present in podocytes as they both can produce similar phenotypes.
Increases in the proportion of the landscape covered by patches of the wild host also increased pathogen population size because of increased wild host abundance.
In contrast to human lung cancer cells where genistein increased wild type but not mutated p53 [ 45], in colon cancer HT-29 cells we showed that genistein increased expression of mutated p53.
From their results they hypothesised that upregulation of bcl-2 is an advantage in tumours where increased wild type p53 promotes apoptosis in response to DNA damage, but where p53 is disabled, this upregulation of bcl-2 is not required to increase tumour growth.
The role of many of these DAF-16 targets for longevity has been functionally tested; RNAi of many genes up-regulated by daf- 2 leads to decreased daf- 2 lifespan and RNAi of many genes down-regulated by daf- 2 leads to increased wild type lifespan (Murphy 2006).
Similar(54)
These results suggest that increased wild-type UCMK expression does not provide a significant enhancement in dFdC-mediated cytotoxicity and may warrant the implementation of studies aimed at engineering UCMK variants with improved activity toward gemcitabine monophosphate.
Therefore, even without sequence mutants, increased wild-type α-synuclein dosage may cause PD.
Taouil and colleagues showed that the long-acting salmeterol treatment increased wild-type CFTR expression in primary human airway epithelial cells.
We have previously shown that overexpression of BRAFWT has no effect on zebrafish, suggesting that developing embryos can compensate for the increased wild-type BRAF activity (Fig. 3A).
These data show that overexpressing the wild-type DVAP is sufficient to induce the disease and that DVAP-V260I is a pathogenic allele with increased wild-type activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com