Also, patients with PBRM1 inactivation are more likely to present with stage III or IV disease, increased tumor size, low differentiation grade, increased perinephric or lymphatic invasion, and are less likely to have an "incidentaloma" at diagnosis (da Costa et al., 2013; Hakimi et al., 2013a; Pawlowski et al., 2013).
PTEN downregulation also increased tumor size following subcutaneous injection of colorectal cancer cells in nude mice.
Ly5.1 mice reconstituted with Cd34−/− bone marrow exhibited increased tumor size on day 19, compared to mice reconstituted with Cd34+/+ bone marrow (Figure 5B).
Knockdown of BNIP3 increased tumor size and induced metastases [ 20].
Additionally, PC with new-onset diabetes may exhibit increased tumor size and decreased postresection survival [ 34].
Filardo's group showed a link between GPER expression and tumor progression and increased tumor size in breast cancer patients [ 40].
In this instance, the T-cell infiltration and inflammation cause the increased tumor size on radiological images.
Thus, loss of these markers but not increased tumor size or higher proliferation rate Mib-1 defined a subgroup of SCLC with particularly poor prognosis.
These data suggest that in mice with a diabetes type II like syndrome carcinoma cells have a higher proliferation rate resulting in increased tumor size.
Increased nodal status, high tumor grade, high Ki67, increased tumor size and negative receptor status (especially PR) are associated with a poorer prognosis [ 24].
Both Linc00974 and KRT19 expression significantly correlated with decreased tumor differentiation grade (P<0.001), increased tumor size (P<0.001), and metastasis (P<0.001).
