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Neither volume nor skewness could separate the groups on a statistically significant level, but the reduced volume with maintained skewness supported our assumption of increased treatment effect size after priming.
27 In the present study, increasing the hours of contact might possibly contribute to an increased treatment effect, but would also imply increased use of resources, and thus make the programme less feasible for primary healthcare.
In terms of treatment effects, we did see an increased treatment effect size among participants who were randomised to their preferred treatment compared with those who were indifferent to the treatment allocation.
The European regulatory body approved rhAPC for multiple organ failure (again based on subset data analysis from the PROWESS trial demonstrating increased treatment effect as the number of organ failures increased).
In the dose response analysis, we conducted a meta-regression analysis of study-specific risk ratios (RRs) by means of weighted linear regression [ 18] to determine whether higher doses are associated with increased treatment effect (i.e., reduction in number of patients requiring supplementary analgesia).
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Consistent with findings from meta-analysis [ 29], the differences in EAS scores between the VIPI and TAU groups just after treatment might be explained by the use of video, which increased treatment effects, not only on parental sensitivity, but also on parent child interaction competence as a whole.
Although improved sleep outcomes after MBSR without added sleep hygiene has been reported [ 17, 18], our focus group findings suggest adding sleep hygiene information may increase treatment effect sizes.
Empirically evidenced deficits in emotion processing in patients with MUS make a CBT enriched with an emotion regulation training (ENCERT) a promising approach to increase treatment effects.
The heterogeneity across studies further highlighted the relevance of the optimization of both psychotherapeutic and pharmacological interventions to increase treatment effects.
Even when drug intake produced anticipated benefits, participants still encountered challenges to their quality of life, with increased treatment side effects being accepted as trade-offs for achieving pain relief from TN (ref 27).
The multimodality strategies may result in increased treatment-related side effects, ultimately leading to increased numbers of patients suffering from transient, persisting or even progressive late side effects (Gartner et al, 2009; Peuckmann et al, 2009; Hill-Kayser et al, 2011).
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