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Whether this was because of increased gene expression, increased translation or post-translational modification is unclear.
Once these athletes fatigue, their rotator cuff cannot alone stabilize the humerus and the increased translation, especially upward or superior-posterior leads to overloading the rotator cuff tendon.
It has been postulated that an increased femoral head diameter may reduce the risk of dislocation as a result of reduced component component or component bone impingement and increased translation that is required for hip dislocation [7, 8, 9].
Activation of 4EBP1 translation initiation factor, on the other hand, leads to increased translation from mRNAs with 5′-untranslated regions such as those for cyclin D1 and c myc, which are crucial to cell cycling (Figure 2).
Thus increased mTORC1 signaling leads to increased translation.
Transfection of VerUTR into the cells facilitated increased translation of versican and fibronectin.
This vector includes an internal ribosomal entry site (IRES) for increased translation of downstream gene inserts.
However, the underlying mechanism responsible for the increased translation in the Balk et al. study was not solely AKT dependent.
However, the presence of short repeats increased translation efficiency in the absence of any change in mRNA levels [59].
Increased translation of PKMζ is necessary for induction and maintenance of L-LTP [48], [4] and PKMζ acts in the vicinity of the synapse [49].
During oncogenesis, dysregulated or dysfunctional miRNA can result in increased translation of oncoprotein(s) and/or decreased translation of tumor suppressor protein(s).
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