Sentence examples for increased trail from inspiring English sources

Poorly differentiated areas in NSCLC showed a strong staining pattern for TRAIL [ 31] and in colorectal cancer an increased TRAIL expression within the tumour was associated with worse overall survival [ 32].

In contrast to the results reported here, Perlman and colleagues [ 27] were unable to detect elevation of TRAIL or TRAIL receptors in synovial fibroblasts but did observe increased TRAIL R3 in RA synovial fluid macrophages.

This might contribute to the increased TRAIL sensitivity of 090 cells; however, further studies will be required to determine whether TRAIL-R upregulation is necessary for TRAIL sensitisation by bortezomib.

Inactivated EBOV also effected increased TRAIL expression in PHM, suggesting that the TNF receptor superfamily may be involved in apoptosis of the host lymphoid cells, and that induction may occur independent of viral replication.

Inhibition of NFAT decreased TRAIL protein expression while overexpression of NFATc1 increased TRAIL promoter activity and increased TRAIL protein and mRNA expression.

Expression of NFATc1 activated TRAIL promoter activity and increased TRAIL mRNA and protein expression.

Interferon-α and the COX-2 inhibitor celecoxib synergistically increased TRAIL-induced apoptosis in hepatocellular carcinoma.

The CDDP-pretreated cells indeed demonstrated more increased TRAIL-mediated caspase-8 activation, loss of mitochondrial membrane potential (ΔΨm), and apoptosis than untreated cells.

Further, knockdown of Akt increased TRAIL-induced growth inhibition while such changes were minimal in cells transfected with control siRNA (Fig. 4A).

Importantly, inhibition of Akt phosphorylation by LY294002 significantly increased TRAIL-induced PARP cleavage as compared to cells treated with TRAIL, or LY294002 alone (Fig. 3A and C).

In contrast, combined IFN-γ and TNFα pre-treatment dramatically increased TRAIL-induced caspase 8 cleavage in the SW620 cells as compared to IFN-γ or TNFα treatment alone (Fig. 2C).