Sentence examples for increased tight from inspiring English sources

DTPA absorption from the lung has received extensive study, typically as an assessment of whole-lung permeability, and increased DTPA absorption rates have been associated with alveolar damage or increased tight junction permeability resulting from pro-inflammatory stimuli.

Previous studies have demonstrated decreased TER in CF epithelial cells [26], so here we sought to determine whether increased DTPA absorption in the CF airway was associated with lower TER and increased tight junction permeability.

For instance, IL-6 markedly induces Claudin-2 expression via MEK and PI3K signaling leading to increased tight junction permeability [ 56].

Increased paracellular permeability of the monolayer was not the cause of these observations, as TEER data showed increased tight junction resistance in monolayers treated with AICAR.

IL-6 has been proposed to play an important role in the regulation of tight junctions in the intestinal epithelium where it stimulates the expression of claudin-2, which is associated with increased tight junction permeability [ 6].

In a chronic hypoxia model of cerebrovascular disease, angiogenesis proceeds in the absence of BBB leakage, being associated with increased tight junction protein expression [ 254]; this demonstrates that angiogenesis is not indissolubly linked to BBB breakdown.

The cessation of milk removal begins the involution process and initially results in distension of the mammary gland followed by a decline in the rate of milk secretion, an increase in intramammary pressure, a decrease in mammary blood flow, increased tight-junction permeability and lactose efflux, and an inflammatory response.

These "traps" are sweet spots for tight oil development, which can significantly increase tight oil production.

In other epithelial cell types TGFβ signalling can increase tight junction adhesion through the proteins FLRT3, Rnd1 and claudin and increase the association of cadherin with β-catenin to promote junction formation [37], [38], [39], [40].

In addition, proinflammatory cytokines have been demonstrated to be capable of increasing tight junction permeability, by inducing the rearrangement of the different tight junction proteins [ 36].

The addition of purified VacA to MDCK cells lowers transepithelial electrical resistance (TER) and increases tight junction permeability to low-molecular weight molecules and ions.