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The therapeutic use of antiangiogenic drugs, for example, bevacizumab and aflibercept, has shown only a little effect, because they elicit tumour adaptation and advancement to stages of greater malignancy, with an increased invasiveness, and in some cases also increased the progression of lymphatic and distant metastases [ 19].
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Multimodal treatment including chemotherapy and radical surgery increased the Progression-Free-Survival (PFS) from 10 to 65%% [ 2].
First-generation agents of this class, like sunitinib or sorafenib, increased the progression-free survival (Baselga et al, 2012; Bergh et al, 2012).
Anti-angiogenic therapy has increased the progression-free survival of many cancer patients but has had little effect on overall survival, even in colon cancer (average 6 8 weeks) due to resistance.
Over the last decade, the improvement of cytoreductive surgical efforts and the introduction of paclitaxel in the upfront platinum-based chemotherapy have increased the progression-free and overall survival of ovarian cancer patients (Berek et al, 1999).
Women were concerned that breast-feeding may increase the progression of HIV, suggesting that international guidelines to promote appropriate infant feeding practices for infants whose mothers are infected with HIV should focus on the mother's health and well-being, as well as the infant's.
Based on these findings, we conjecture that the absence of cystatin C also may increase the progression and growth of other types of tumors.
Oestrogen and prolactin are thought to increase the progression of murine SLE.
However, whether OSA itself initiates or increases the progression of these abnormalities is entirely unknown.
Likewise, mothers in Malawi [ 19] felt that exclusive breastfeeding would increase the progression of HIV.
This change induces systemic inflammation and potentially increases the progression of chronic arthritis.
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