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The preliminary experiment showed that 3 h was suitable for the cellular uptake of exosomes; incubating for a longer time increased the aggregations of exosomes and the difficulty in counting (Fig. S2).
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Intriguingly, it increased the aggregation of ARQC 65 -CFP/YFP (Fig. 3ARQC 65 -CFP/YFP
Nonetheless, co-expression of NLK-WT still increased the aggregation rate of this mutant AR.
Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes.
Moreover, with the heating/cooling step increasing, the aggregation and disaggregation temperatures are decreased.
An increased exposure of the NAC region due to changes in pH 14,17, addition of polycations14,16, or changes in ionic strength (see Fig. 4) can increase the aggregation propensity of αS.
It was found that the smallest concentration of K+ and the greatest concentration of Mg2 + were required to increase the aggregation rate.
As the concentration of solute Ni increasing, the aggregation degree of solute Ni atoms in CPGA models plays more and more important role.
In addition, it increases the aggregation of soil particles, the water-holding capacity, P-availability, and the quantity of microflora (Watanabe and Roger, 1984).
This suggests that QA-induced phosphorylation at this site may increase the aggregation of tau.
First that it increases the aggregation factors of both unsupervised and supervised maps, which means that the smoothed matrix represents better the correlation between the 5BLC/BLC6 training vectors.
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