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We observed that DE can cause increased symptomatic illness under controlled conditions, and that CII score may predict heightened sickness symptom responses to DE.
In confirmation of this, several recent clinical trials in which rhEPO was administered to cancer patients were terminated following increased symptomatic or fatal thrombosis in patients receiving the drug [ 43- 46].
In recent years the importance of extending research in the area of psychosis to include those who report psychotic symptoms in the general population has been highlighted as a new approach to identifying individuals at increased symptomatic risk for developing a psychotic disorder [ 1]–[ 3].
A systematic review and meta-analysis of 12 randomized controlled trials of IV rtPA given within 6 h of an ischaemic stroke in over 7000 patients confirmed that, in the first 7 days, IV rtPA significantly increased symptomatic intracranial haemorrhage (5.8%), fatal intracranial haemorrhage (2.9%) and death (2.5%) [ 84].
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However, the use of t-PA is limited by a 3 h therapeutic time window after stroke, and is complicated by its side effects of increasing symptomatic intracerebral hemorrhage [14].
Our data, along with those of others [ 20], indicate significantly increasing ReQuest™ scores (reflecting increasing symptomatic burden) of GERD overlapping with dyspeptic and/or IBS-like complaints.
Clients sometimes experience painful crises that place their live in turmoil and increase symptomatic behaviour; the case managers are a first line of intervention to minimise the potential for regression or relapse" (p.308).
Toda et al. found a significant correlation between the number of steps per day and increasing symptomatic relief of knee OA pain (p = 0.003, r = -0.58) and decreasing body fat (p = 0.012, r = -0.62) [ 52].
In patients with polymyositis and dermatomyositis, IL-1α was found to be expressed in endothelial cells and inflammatory cells, and significantly increased in symptomatic when compared with non-symptomatic muscle tissue.
Importantly, the levels of LMP2, a inducible subunit of immunoproteasome, was increased in symptomatic Als2−/−;SOD1H46R mice (Figure 4), consistent with recent findings [39], [40].
Unfortunately due to small sample sizes, we were unable to examine, for each RTI separately, whether HIV shedding was higher during symptomatic vs. asymptomatic infections, and therefore investigate a hypothesis proposed by Johnson et al. [3] that since leukocyte concentrations are more likely to be increased with symptomatic infections, these may have a greater effect on HIV shedding.
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