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We postulated initially that the relationships found between side effects and the parent-rated therapeutic response could be due to a shared biological mechanism, meaning that with increased therapeutic effects there will be also increased side effects.
The danger of aiming for the host could be increased side effects.
It significantly increases the risks, due to drug synergy and increased side effects.
More problematic still is the fact that patients with both sets of symptoms may respond poorly to standard ADHD treatments or have increased side effects.
By blocking the metabolism of these benzodiazepines, the serum concentrations of the benzodiazepines may increase and have increased side effects (i.e. increased sedation, dizziness, impaired cognition).
First, we assumed that combination therapy would have to be superior to the next best single-agent therapy in order to be preferred, because of complexity, costs, increased side effects, etc.
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They reduce the rate of elimination of the benzodiazepines that are metabolized by CYP450, leading to possibly excessive drug accumulation and increased side-effects.
Some families believed lag-time contributed to poorer medical outcomes, more complicated treatment or increased side-effects.
Later in the disease trajectory, patients may be prescribed more medication leading to increased side-effects and the association between HbA1c and QoL may therefore change.
About one third of patients expressed worries after generic substitution and some reported either a reduced effect or new or increased side-effects [ 6, 7].
In the other two studies using amoxicillin-clavulanate showed considerable benefit although at the cost of increased side-effects [ 26, 27].
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CEO of Professional Science Editing for Scientists @ prosciediting.com