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Interestingly, absence of AhR ligands increased severity of colitis in mice; when animals were fed with diet enriched in AhR ligands, observed alterations were reversed.
Gpa33 –/– mice exhibited hypersensitivity to food antigens and a markedly increased severity of colitis upon exposure to DSS.
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● Increased severity of infections [ 18].
Agreement decreased with increasing severity of dementia.
Total lymphocyte counts decreased with increasing severity of HIV disease.
The last 12 months have underscored the increasing severity of California wildfires.
In the last couple of years we have seen increasing severity and public exposure to cyberattacks.
Fear of job loss often overrides reporting pain, increasing severity.
Further, the depletion of Foxp3+ Treg from Foxp3-GFP-DTR mice increased the severity of acute dSS-colitis accompanied by 80% lethality of Treg-depleted mice.
de Yong et al. demonstrated that the expression of MIF was increased in a model of experimental colitis induced by the transfer of CD45RB high, and that blockade of MIF with anti-MIF antibody reduced the severity of colitis.
Loss-of-function variants of the IL23-receptor gene (IL23R) protect against IBD, and, in animals, blocking IL23 reduces the severity of colitis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com