Changes in joint pathology often result in an increased sensitization of primary sensory neurons and central sensitization, due to the changes in ascending or descending modulatory pathways [ 52].
MOH patients carrying the D/D polymorphic variant of the angiotensin converting enzyme (ACE), that plays a role in neural plasticity and dependence behaviour, showed less SSEP habituation, in proportion with the duration of the overuse headache, and increased sensitization depending on the overused drug compared to I carriers [89].
Prolonged peripheral nociceptive input has been reported to increase sensitization to peripheral pain via sensitization of the central mechanisms, resulting as CTTH [9, 10].
Bitterfeld children, on the other hand, more often received a diagnosis of asthma and eczema than children residing in Zerbst and also showed slightly increased sensitization rates.
On the other hand, excessive band-selective filtering may lead to paranoia; indeed, increased sensitization and reduced habituation are trait markers of patients with schizophrenia [ 179].
Other client-level factors that hinder access to facility deliveries can be addressed through increased community sensitization on the importance of seeking care.
Secondary hyperalgesia is increased sensitivity in normal tissue near an injury, and it is a measure of central sensitization reflecting injury-related effects on the CNS.
Our studies on increased anoikis sensitization in matrix metalloproteinase-2 (MMP-2 -knockdown MMP-2 -knockdownMMP-2 -knockdownraft cells were interestingly correlated with p21-activated kinase 4910and) inhibition, prompting us to further investigate the role of PAK4 in glioma.
Repeated intermittent cocaine administration produces a progressive increase (sensitization) in the motor stimulatory action of cocaine.
The common facilitating factors that emerged across the study sites included the policy of removal of user-fees (100%), the increasing level of community sensitization on health issues (90%), the prohibition of TBAs from undertaking deliveries, which had directly pushed some women to deliver at health facilities (75%), and the delivery of some services at community level.
