These changes appear to be independent of alterations in gustatory sensitivity, since any changes in this measure would have resulted in horizontal shifts to the right for decreased (tolerance) or left for increased (sensitization) gustatory sensitivity.
In the present study, both increased sensitization and reduced habituation appeared to be trait markers of schizophrenic psychoses.
This might be due to the enhanced level of deposition of nanocrystalline HgS onto the bare photoanodes of TiO2 with increased sensitization time.
Any increased sensitization of the nociceptive receptors could affect the response of the afferent nerve fibers, causing central hyperexcitability of the neurons in the dorsal horn of the spinal cord affecting trigeminal nucleus and facilitating headache symptoms.
Increased sensitization of the nociceptive receptors could affect the response of the afferent nerve fibers, causing central hyperexcitability of the neurons in the dorsal horn of the spinal cord, leading to plastic changes in spinal and/or supraspinal levels.
However, an intra-accumbens shell injection of CP 93129 (10 30 μg/side) increased sensitization to cocaine, and this enhancement was attenuated after local injection of GR 55562 (1 μg/side).
MOH patients carrying the D/D polymorphic variant of the angiotensin converting enzyme (ACE), that plays a role in neural plasticity and dependence behaviour, showed less SSEP habituation, in proportion with the duration of the overuse headache, and increased sensitization depending on the overused drug compared to I carriers [89].
This controlled for potential effects of repeated sucrose stimulation that could lead to increased sensitization or habituation.
In line with this theory, R mice in this study should therefore have exhibited increased sensitization as compared to NR mice.
Prostate cancer cells demonstrated a decreased DNA repair capacity and an increased sensitization to chemical- and radio-DNA damaging agents upon HDAC inhibition.
Taken together, the IFNAR1 expression data from the colitic and healthy mice, as well as the effect of IFNAR1 loss or downregulation in IFNAR1−/− mice or in vitro cultures respectively, suggest that the loss of IFNAR1 expression may correlate with a decreased ability to generate Tregs, which in the course of DSS colitis may ultimately lead to increased sensitization.
