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(ii) Transgenic mice overexpressing ADK display increased sensitivity to brain injury and seizures.
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Anterior and temporal brain regions have particularly high glucose demands and increased sensitivity to glucose disruption (1); thus, it not surprising that these brain regions show reduced brain volumes, altered T2 relaxation times, and metabolite changes.
This increased sensitivity to Slc9a6 loss of function in the female mouse brain could be due to stochastic events in our study and not necessarily genetic predetermination.
Other abnormalities reported in CRND8 mice included increased stereotypic behavior [ 29], brain inflammation [ 30] and increased sensitivity to experimentally induced seizures [ 31].
Notably, increased sensitivity to mild pain in older females was reflected via less brain deactivation in regions associated with both the DMN and in pain affect.
During a migraine attack, a number of changes occur throughout the brain causing dilation of blood vessels; severe pain; increased sensitivity to lights, sounds and smells; nausea and vomiting; and other symptoms.
A PFK1 isoform with reduced sensitivity to citrate inhibition (Ki = 0.75 mM citrate) and increased sensitivity to activation by F2,6P was described in human glioma cells (as compared to the enzyme from normal brain tissue (Ki = 0.1 mM citrate); [32].
(f) Increased sensitivity to light and sound?
Increased sensitivity to light and sound II.
This could be the result of increased neuronal sensitivity to capsaicin, increased release of CGRP or increased sensitivity to CGRP.
As we grow older, we have an increased sensitivity to environmental allergens (you probably already knew that).
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