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Mice receiving GW501516 also exhibited increased running time (2.5-fold) and distance (2.7-fold) to failure relative to those receiving vehicle; however, these differences were not statistically significant.
On average, aging 1 year increased running time 0.2%, or 9 s (P < 0.001).
At first we were concerned that the RECLU program would have a dramatically increased running time compared with the original Paraclu.
In addition, this intervention also improves mouse neuromuscular function, and affects balance and motor coordination (improved rotarod performance, increased running time and consumption of oxygen in muscle fibers) [ 29, 30].
Because of increased running time, budget and facilities, the team were able to include more cels in animations, as well as longer and more intricate action sequences.
In the following, we only consider m = 5, while our conclusion can be generalized to larger m with increased running time.
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However the improvement over a much simpler fast-descent swap heuristic was very slight, but at the cost of greatly increased running times.
Clearly, running times depend on molecule masses, see again Table 2. Increasing the blowup beyond 5 × 10 increased running times, presumably because the smaller table can be kept in the processor cache.
Mice of all genotypes showed significantly increased running times by reducing their speed in trials with tones (70 dB tone: F1,18 = 5.48, p < 0.05; 90 dB tone: F1,18 = 9.18, p < 0.01; Fig. 7c) and flash lights (F1,18 = 92.06, p < 0.0001; Fig. 7c) compared to non-distracted trials.
Even though proteomics practitioners are accustomed to bottom-up methodologies; the digestion process results in increased cost, increased run time and grossly increased sample complexity as compared to classical ELISA.
The times required at a mismatch tolerance of ≤3 are comparable to those reported for other recently developed tools (Li et al., 2008), and it should be noted that although setting the tolerance above three results in a significantly increased run time, the amount of usable sequence data increases dramatically as well.
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