Sentence examples for increased reversion from inspiring English sources

The increased reversion rates in the trp5 –A149G strains (GC → AT transition) is likely due to oxidized cytosines resulting in C → T transitions (Kreutzer and Essigmann 1998).

However, for any of the strains, it is difficult to know what types of base damages are the ones likely causing the increased reversion rates.

Because we expect nearly all of the increased reversion events in the trp5 –A149C ogg1 strain to be due to 8-oxoG-A mispairs, which is a substrate for MMR, the increased reversion rate of the ogg1 strain must be due to overwhelming the MMR system.

In all these trials, acarbose was shown to effectively reduce hyperglycaemia, and in STOP-NIDDM, acarbose also significantly increased reversion of IGT to normal glucose tolerance (P < 0.0001)[ 7].

Automated analyses revealed that the partial suppression of vt29 by overexpression of GFP DAT-1 does not derive from an increased reversion probability or latency to paralyze (Table 1) but rather appears to result from a reduction in Swip penetrance, with a reduced fraction of animals swimminGFP DAT-1ear the rates observedoesth vt29 alonot

Pol η is necessary for accurate bypass of 8-oxoG (Haracska et al. 2000; Yuan et al. 2000; De Padula et al. 2004; Carlson and Washington 2005) and thus one would expect to observe an increased reversion rate in the trp5 A149CC strain in the absence of Pol η.

Table 2 shows that deletion of RAD30 in ogg1 strains increases reversion rates by 2.7- and 2.3-fold in F and R strains, deleting MSH6 increases reversion rates by 8.1- and 9.2-fold, and deletion of both increases reversion rates by 30- and 32-fold, respectively.

We further find evidence that template switching is important for avoiding mutagenesis due to 8-oxoG, as inactivation of either RAD5 or MMS2 significantly increases reversion rates.

Removal of MMR had drastically different effects in the two sets of strains, increasing reversion rates by up to orders of magnitude in the cyc1 strains and only modestly in the trp5 strains.

Cr VI) has been shown to increase reversions (i.e. mutations) in Salmonella typhimurium and Escherichia coli; however, mutation formation is mitigated by the addition of S9 (De Flora, 1978; NTP, 2008b; Petrilli & De Flora, 1978a, b).

Increase of penicillin G (Pen G) concentration from 600 µg (1000 units)/ml to 6000 µg (10,000 units)/ml in LIM did not appear to affect the ability of the bacteria to form L-form colonies, but increased the reversion time of L-form colonies to classical colonies from 2 days to 5 days.