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Exceptions are the studies by De Croos De Crooss et al. 2006) who find increased response at a low magnitude of 0.001 MPa applied for less than 1 h, and by Hu and Athanasiou (Hu and Athanasiou 2006) who did not find a change in the E-modulus after prolonged loading for 160 h.
The increased response at low shear was partially dependent upon the generation/availability of thrombin, as hirudin treatment significantly reduced Ca2+ responses at 200 s−1.
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Increased responses at 0.5 μg E2/kg bw/day were significant in CD-1 mice but did not reach significance in C57Bl6.
From all these data, we concluded that the increased response to AT-II in diabetic aortas could be explained by an over-activation of some transduction system(s) coupled to AT-II receptors.
The first adaptation significantly increases responses at the new preferred orientation by 27% from 6.2 Hz±0.9 Hz to 8.5 Hz±1.1 Hz (paired sample two-tailed t-test, p<0.0001).
The existing algorithms of linear response to external forcing are vulnerable to the time scale separation due to increased response errors at fast scales.
In both studies, the combination arm produced increased response rates but at the expense of higher toxicity.
The quadruple mutant has a BR-response phenotype and showed increased response to BL (especially at 100 nM BL) compared with WT (Fig. 1d).
Significant deficits in radial-arm maze choice accuracy performance were found at 78.7 micrograms/side for methyllycaconitine and at 106.9 micrograms/side for dihydro-beta-erythroidine. Increased response latency was also seen at these doses.
Radiation oncologists aim to integrate oxaliplatin during radiotherapy as a radiosensitiser to increase response (usually at sub-systemic doses for tolerability).
Maintenance chemotherapy postcompletion of chemoradiation should be explored in future studies in those who show sensitivity to treatment as the higher cumulative doses received may increase response rates at distant sites.
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