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In this case an increased response and a more phase sensitive amplitude (phase between excitation frequencies) is obtained, as compared to the case with either pure quadratic or cubic nonlinearity.
Voriconazole, introduced in the 1990s, is a third generation azole and current "gold standard" for invasive disease and has increased response and survival rates by 15 20%.
While added trastuzumab increased response and survival rates in each of these strata, combination with anthracyclines unexpectedly increased cardiotoxicity [ 7] (although less markedly with epirubicin [ 8]), impeding its widespread use and favoring taxane-oriented strategies.
A decreased activity of MTHFR results in higher 5,10-methylene tetrahydrofolate levels which leads to inhibition of thimidylate synthase and consequently to DNA damage [ 45- 47] leading theoretically to an increased response and survival.
Recent studies have helped to form the opinion that these advanced stage patients may be treated with paclitaxel and platinum therapy, due to increased response and survival rates with the combination (McGuire et al, 1996; Du Bois et al, 1999; Ozols et al, 1999; Piccart et al, 2000; Neijt et al, 2000).
Grimshaw et al. observed that an increase in dose of "component interventions" did not always lead to an increased response and proposed that multi-faceted interventions should be "built upon a careful assessment of barriers and a coherent theoretical base" [ 27].
Similar(53)
Therefore, strategies to increase response and reduce missingness are required.
This allows the ability to uncover those characteristics and clusters, most important in identifying target households for the purpose of increasing response and purchase rate.
In other words, the combination of BRAF and MEK inhibitors results in an increased response rate and prolonged PFS [24].
Identified prefrontal neural predictors might propel the future development of fMRI markers for clinical decision making, which could lead to increased response rates and adherence during acute phase treatment periods.
Trastuzumab therapy has increased response rates and survival times in the metastatic setting [ 15].
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