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Likewise, subchondral bone in OA animal models with early stages of the disease have shown both decreased volume and stiffness [ 28, 29], and increased remodelling [ 29].
This markedly increased remodelling was accompanied by significantly more dilation both in systole and in diastole and an exacerbation of the banding-induced fall in ejection fraction.
Increased remodelling activity of the bony part in the transplant was seen at six months compared to two months (unpublished data).
Conceivably, increased remodelling, as is seen in the nearly hip fracture-free Gambians with their low calcium diet and high indices of bone remodelling [165] might result in tougher but less dense bone tissue due to higher osteocyte survival, less hard matrix and less advanced secondary mineralisation.
Microstructure impairment at subchondral bone associated with an increased remodelling aggravated cartilage damage in OA rabbits with previous OP.
Another cause of increased remodelling is the secondary hyperparathyroidism associated with reduced vitamin D levels, commonly seen in the elderly.
Similar(49)
Rats after sham surgery manifested a very low-rate mandibular remodeling, whereas OVX rats disclosed significantly increased remodeling rates.
The increased acid phosphate parameter in the fracture region indicated increased remodeling activity or younger tissue in these regions.
All our patients with incomplete fractures showed numerous osteoclasts and increased remodeling in the cortical bone adjacent to the fracture.
The increased remodeling in OA bone could possibly account for the observation of hypomineralization of the subchondral bone tissues in established OA [ 9- 11].
Early-stage OA increases remodelling and bone loss of both trabecular and cortical subchondral entities (the two parts of the subchondral bone), whereas late-stage OA decreases remodelling and increases subchondral plate densification (Burr & Gallant 2012).
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