Cord blood mercury was associated with both adverse and potentially beneficial effects on early auditory information processing, with increased reaction time and increased latency but fewer false alarms (i.e., false-positive errors) and greater amplitude of response on the auditory ERP task (Boucher et al. 2010).
Globally increased reaction-time latencies have also been associated with decreased general executive factors and inattentive behavior [ 27].
Asterisks (*p<0.05, **p<0.01) indicate elevated ICSS thresholds or increased response latencies compared with the saline saline group.
Response latencies did not differ between exposed and control monkeys, indicating the effects were not due to increased reaction time (Gilbert and Rice 1987).
Reduced neural resources potentially causes increased reaction time to the inhibitory input or increased time estimation variability, which in combination would account for prolonged latency.
An increase in substrate concentration does not increase reaction rate.
The effects of indomethacin or minocycline compared to vehicle treatment were 31.4 ± 10.9% and 43.2 ± 16.0% increase in reaction latency time after treatment with minocycline or indomethacin, respectively, compared to 2.1 ± 7.4% after vehicle treatment.
However, the coadministration of minocycline 50 mg/kg and CAY10404 10 mg/kg resulted in a significant increase in reaction latency (p < 0.01) at 1 hour post treatment compared to vehicle or minocycline alone, respectively (Table 3).
However, both drugs showed a tendency to have some antinociceptive activity at 1 hour post treatment (increased percentage change in reaction latency after treatment compared to before treatment) in mice with LPS-induced thermal hyperalgesia.
However, the coadministration of indomethacin 5 or 10 mg/kg and minocycline 50 mg/kg resulted in an increase in the reaction latency time compared to vehicle treated animals or indomethacin or minocycline alone.
30, 50, 51 In addition, and more importantly because of their discriminative properties in the cluster analysis, other CANTAB test results (RTI and RVP) were also affected by aging, suggesting that reduced processing speed (which appears to progress linearly with age) is associated with increased latency and reaction time.
