Sentence examples for increased rate of major bleeding from inspiring English sources

Both doses of rivaroxaban reduced the risk of MI and cardiovascular mortality (8.9%/year vs 10.7%/year, P=0.008) with an increased rate of major bleeding (2.1%/year vs 0.6%/year, P<0.001).

The Warfarin-Aspirin Reinfarction Study (WARIS II) included 3,630 patients after MI and demonstrated that warfarin was superior to aspirin in decreasing ischemic events following MI (16.7%/year vs 20%/year, P=0.03) but was associated with an increased rate of major bleeding (0.62%/year vs 0.17%/year, P<0.001).

The reduced dose was not associated with an increased rate of major bleeding, but the trade-off was an increased rate of myocardial infarction and of early mortality, in particular in case of anti-Xa activity lower than <0.5 IU/mL.

In atrial fibrillation patients, however, from the RE-LY trial, concomitant intake of clopidogrel and dabigatran etexilate led to an increased rate of major and any bleeding [ 24].

47 In their study on UFH for initial treatment of DVT, Campbell et al showed an increased rate of bleeding and major bleeding in patients ≥72 years, compared with those under 72 years (14.1% versus 7.1% for bleeding and 11.1% versus 3.1% for major bleeding).

A recent meta-analysis of clinical trials showed that rate of major bleeding events increased with higher doses of aspirin.

Advanced age, however, was clearly associated with an increased rate of bleeding complications.

However, the rate of major bleeding events was higher in fondaparinux- than in enoxaparin-treated patients in both groups.

Apixaban was associated with slightly increased rates of non-major bleeding (11% v 8% vitamin K antagonists) and discontinuation (13% v 8% vitamin K antagonists).

1, 21, 22 CKD patients are also associated with a twofold increased risk of major bleeding.

GP IIb/IIIa inhibitor use was associated with an increased risk of major bleeding.