Sentence examples for increased radiation sensitivity from inspiring English sources

To the best of our knowledge, the specific strain used in this study has not been categorized regarding DNA repair deficiency, but it is assumed that the genetic background exhibits similarly increased radiation sensitivity.

Likewise, YB-1 siRNA increased radiation sensitivity.

Likewise, siRNA targeting of YB-1 increased radiation sensitivity tested in MDA-MB-231 cells.

Downregulation of filaggrin-2 resulted in an increase in caspase-3 activation, showing increased radiation sensitivity.

It has however been shown that particular alterations in the ATM gene are associated with increased radiation sensitivity [ 22– 22].

It is possible that the increased radiation sensitivity is simply a consequence of the attenuation of IR-induced G2/M arrest by Rac1 inhibition.

Mutations in other genes that act in HR have been reported to increase radiation sensitivity by only ∼2-fold or less (Thompson and Schild, 2001).

Low expression of Beclin1 was also related to distant metastasis risk in breast cancer [ 46] and recently we demonstrated that the combined silencing of EGFR and induction of autophagy by rapamycin has additive effects both in increasing radiation sensitivity and in inhibiting cell migration ability, in U373 and T98G GB cells [ 25].

These data suggest that RPS3 knockdown increases radiation sensitivity and phenocopies the effect of Lxn overexpression.

Reduced NF-ĸB activity in mice increases radiation sensitivity and results in greater lethality from whole-body radiation exposure (Wang et al. 2004), consistent with a radioprotective role for NF-ĸB.

The previous study shows that DNA-PKcs is inactivated by phosphorylation at Thr 3950, and thus PP6c overexpression possibly enhances the IR-induced DNA-PK activation through dephosphorylation of Thr 3950, which is one possible mechanism by which PP6c knockdown increases radiation sensitivity of GBM cells.